653592-04-2

MT-DADMe-ImmA is an inhibitor of 5''-methylthioadenosine phosphorylase (MTAP; K_i = 1.7 nM). It increases levels of MTA , a product of polyamine metabolism, in FaDu human squamous cell carcinoma cells when used at a concentration of 1 μM. MT-DADMe-ImmA (5, 9, and 21 mg/kg per day for 28 days) reduces tumor growth in a FaDu mouse xenograft model.

MT-DADMe-ImmA is an inhibitor of human 5'-methylthioadenosine phosphorylase (MTAP) with a Ki of 90 pM.

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