L-β-ethynylserine (βES) is a threonine analog. L-β-ethynylserine is efficiently incorporated into newly synthesized proteins, and allows their selective visualization or enrichment through bioorthogonal ligation to fluorescent dyes or affinity tags,
respectively.
Definition
ChEBI: L-beta-ethynylserine is a non-proteinogenic L-alpha-amino acid that is L-propargylglycine which is carrying a hydroxy group at the 3R position. It has a role as an antimetabolite, an antibacterial agent, a bacterial metabolite and a fungal metabolite. It is a terminal acetylenic compound and a non-proteinogenic L-alpha-amino acid. It is functionally related to a L-propargylglycine. It is a tautomer of a L-beta-ethynylserine zwitterion.
References
[1] Ignacio BJ, Dijkstra J, Mora N, et al. THRONCAT: metabolic labeling of newly synthesized proteins using a bioorthogonal threonine analog. Nat Commun. 2023;14(1):3367. DOI:10.1038/s41467-023-39063-7
