651055-83-3

6-Amino-8-trifluoromethylphenanthridine (6A-8tFP) is an antiprion agent and a derivative of 6-aminophenanthridine . It inhibits protein folding activity of the ribosome (PFAR) when used at a concentration of 150 μM. 6A-8tFP directly competes with protein substrates for the ribosomal active site.

6-Amino-8-trifluoromethylphenanthridine (6A-8tFP) is an antiprion agent and a derivative of 6-aminophenanthridine (HY-135189). It inhibits protein folding activity of the ribosome (PFAR) when used at a concentration of 150 μM.2 6A-8tFP directly competes with protein substrates for the ribosomal active site.

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[1] Bach, et al. Isolation of drugs active against mammalian prions using a yeast-based screening assay. Nat. Biotechnol. 21(9), 1075-1081 (2003).