65043-22-3

Indeloxazine hydrochloride is a nootropic indicated for the treatment of senile dementia. In animal models indeloxazine reportedly enhances brain energy metabolism and monoamine content; its claimed protective effect on ischemia-induced amnesia is supported by the prolonged step-through latency in passive avoidance tests.

Yamanouchi (Japan)

Antidepressant.

Elen

After oral administration of indeloxazine hydrochloride to rats, two conjugates, which are labile to a- glucosidase hydrolysis but refractory to b-glucosidase, are isolated from the urine and identified as a-D- glucopyranosides of trans-4-(2-morpholinylmethoxy)- 1,2-indandiol and trans-6-[[(1,2-dihydroxy-4- indanyl)oxy]-methyl]-3-morpholinone.