ChemicalBook CAS DataBase List 646530-37-2

646530-37-2

Name	3-Isoxazolecarboxamide, N-(2,4-dichlorophenyl)-5-methyl-
CAS	646530-37-2
Molecular Formula	C11H8Cl2N2O2
MDL Number	MFCD08724989
Molecular Weight	271.1
MOL File	646530-37-2.mol

Chemical Properties

Boiling point	336.2±42.0 °C(Predicted)
density	1.469±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
form	Solid
pka	9.45±0.70(Predicted)
color	White to off-white

Safety Data

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P280-P301+P312-P302+P352-P305+P351+P338

Hazard Information

Spectrum Detail

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Animal Model:	C57BL/6, male mice (8-10 weeks)
Dosage:	15, 30, and 60 mg/kg
Administration:	Ip; before irradiation, daily x 5
Result:	Blood levels of TGF-β were lowered.

Animal Model:	BDF1 female mice
Dosage:	Po; daily for 4 days
Administration:	60 mg/kg (30 min before ip injection of Cisplatin at 10, 15, and 20 mg/kg respectively on Day 0)
Result:	Increased the survival rate and delayed the time to death for mice treated with 150% of the maximum tolerated dose (MTD) of Cisplatin (15 mg/kg). At 200% of the MTD of Cisplatin (20 mg/kg), treatment of UTL-5g increased the survival rate and delayed the time to death.

646530-37-2

Chemical Properties

Safety Data

Hazard Information

Biological Activity

in vitro

in vivo

Spectrum Detail

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