Chemical Properties
Off-White Solid
Originator
Tridesilon,Dome,US,1972
Uses
Anti-inflammatory. Desonide has also been found as an impurity in budesonide (B689490).
Definition
ChEBI: Triamcinolone acetonide with hydrogen instead of the fluorine substituent at position 9. A corticosteroid anti-inflammatory, it is used topically as a cream, ointment or lotion for the treatment of various skin disorders.
Indications
Desonide (DesOwen, Tridesilon) is a synthetic corticosteroid.
Manufacturing Process
Preparation of 11β,21-Dihydroxy-16α,17α-Isopropylidenedioxy-1,4-
Pregnadiene-3,20-Dione: A solution of 11β,16α,17α,21-tetrahydroxy-1,4-
pregnadiene-3,20-dione (40 mg) in acetone (10 ml) containing hydrochloric
acid (three drops; d 1.19) is boiled 3n the steam bath for two minutes and then allowed to stand for eighteen hours at room temperature. The reaction
mixture is diluted with water (50 ml) and extracted with chloroform (3x25
ml), the combined extracts then being washed with water (30 ml) and dried
over anhydrous sodium sulfate. The residue obtained by removal of solvent
crystallized from ethyl acetate-petroleum ether as small plates (25 mg),
melting point 257°-260°C.
Brand name
Desowen (Galderma); Tridesilon (Perrigo).
Therapeutic Function
Antiinflammatory
References
[1] Patent: CN103421075, 2017, B. Location in patent: Paragraph 0037-0039
