Uses
2,5-Dibromoterephthalaldehyde is an organic compound, mainly used as an organic synthesis intermediate and pharmaceutical intermediate, and is widely used in laboratory research and development processes and chemical production processes.
Synthesis
GENERAL METHOD: Compound 2d (302 mg, 0.516 mmol) was dissolved in ethanol (10 mL), followed by the addition of an aqueous (4 mL) solution of silver nitrate (369 mg, 2.17 mmol). The reaction mixture was heated to reflux for 40 min under argon protection. Upon completion of the reaction, the solution was allowed to cool to room temperature, the resulting silver bromide precipitate was removed by filtration, and the precipitate was washed with ethanol (2 x 5 mL). After removal of the solvent by evaporation, the residue was purified by recrystallization (solvent hexane) to give the target product 3d (146 mg, 94% yield) as a white solid.
References
[1] Angewandte Chemie - International Edition, 2014, vol. 53, # 26, p. 6786 - 6790
[2] Angew. Chem., 2014, vol. 126, # 26, p. 6904 - 6908,5
[3] Synthesis (Germany), 2016, vol. 48, # 20, p. 3509 - 3514
[4] Chemical Communications, 2017, vol. 53, # 53, p. 7266 - 7269
[5] Helvetica Chimica Acta, 1944, vol. 27, p. 274,290
