6343-93-7

4-Methoxyphenylacetamide is a useful reagent in the preparation of novel pyrrolidone-??based derivatives as potential p53-??MDM2 inhibitors for use as potential antitumor agents.

General procedure for the synthesis of 4-methoxybenzeneacetamide from p-methoxybenzeneacetonitrile: Ni NPs/HT catalyst (0.05 g) was added to a thick-walled pressure tube, followed by water (4 ml) and p-methoxybenzeneacetonitrile (1 mmol). The reaction mixture was placed in an oil bath at 120 °C and stirred vigorously. The reaction process was monitored by TLC analysis. Upon completion of the reaction, the reaction mixture was extracted with ethyl acetate and subsequently filtered to remove the catalyst. The filtrate was cooled to 0 °C to allow white crystals to precipitate. The crystalline product was collected by simple filtration and dried under vacuum at room temperature to give analytically pure 4-methoxyphenylacetamide. If the product did not precipitate, the reaction mixture was extracted with ethyl acetate followed by purification by silica gel column chromatography to finally obtain 4-methoxyphenylacetamide.

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