63335-25-1

Malabaricone C is a diarylnonanoid that has been found in Myristica and has diverse biological activities. It scavenges 59.9% of 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals when used at a concentration of 7 μg/ml. Malabaricone C is active against S. aureus, B. subtilis, and C. albicans in vitro (MICs = 2-32 μg/ml). It is cytotoxic to A549, HL-60, and MCF-7 cells (IC₅₀s = 12.3, 46.1, and 10.8 μM, respectively). Malabaricone C inhibits sphingomyelin synthase 1 (SMS1) and SMS2 activity in cell lysates (IC₅₀s = 3 and 1.5 μM, respectively). It decreases body weight gain, hepatic steatosis, and hepatic and plasma triglyceride levels in a mouse model of high-fat diet-induced obesity when administered at a dose of 0.1% in the diet.

Malabaricone C is a useful research chemical compound from Myristica malabarica which exhibits antioxidant activity.

ChEBI: A natural product found in Myristica cinnamomea.

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[2] KHALED Y. ORABI  Farouk S E F  Jaber S Mossa. Isolation and Characterization of Two Antimicrobial Agents from Mace (Myristica fragrans)[J]. Journal of Natural Products , 1991, 54 3: 856-859. DOI: 10.1021/np50075a017
[3] PARINUCH CHUMKAEW  Theera S. New neolignans from the seeds of Myristica fragrans and their cytotoxic activities[J]. Journal of Natural Medicines, 2018, 73 1: 273-277. DOI: 10.1007/s11418-018-1246-2
[4] MUHAMADAQMAL OTHMAN. Malabaricone C as Natural Sphingomyelin Synthase Inhibitor against Diet-Induced Obesity and Its Lipid Metabolism in Mice[J]. ACS Medicinal Chemistry Letters, 2019, 10 8: 1154-1158. DOI: 10.1021/acsmedchemlett.9b00171