240797-64-2

Name	1-Propanone, 1,3-bis(2,4-dihydroxyphenyl)-
CAS	240797-64-2
Molecular Formula	C15H14O5
Molecular Weight	274.27
MOL File	240797-64-2.mol

Synonyms

Tyrosinase-IN-11 1,3-Bis(2,4-dihydroxyphenyl)propan-1-one 1-Propanone, 1,3-bis(2,4-dihydroxyphenyl)-

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Chemical Properties

Melting point	228-229 °C
Boiling point	578.3±35.0 °C(Predicted)
density	1.429±0.06 g/cm3(Predicted)
form	Solid
pka	7.70±0.35(Predicted)
color	Pink to orange

Hazard Information

Uses

Tyrosinase-IN-11 is a potent tyrosinase inhibitor with IC50s of 50 nM and 64 nM for L-tyrosinase and L-dopa, respectively. Tyrosinase-IN-11 has significant antioxidant activity and low cytotoxicity. Tyrosinase-IN-11 has the potential for skin hyperpigmentation research[1].

in vivo

Tyrosinase-IN-11 (compound 11c; 0.5, 1 mM; topical administration before UV radiation every day for 2 weeks or after exposure to UV lamp for 5 days/week for two consecutive weeks) exhibits powerful antimelanogenesis ability in a guinea pig model in vivo^[1].

Animal Model:	Female guinea pigs (10 weeks old, 350-500 g) received ultraviolet exposure from a UV lamp^[1]
Dosage:	0.5, 1 mM
Administration:	Topical administration before UV radiation every day for 2 weeks or after exposure to UV lamp for 5 days/week for two consecutive weeks
Result:	Inhibited the production of melanin in a dose-dependent manner.

References

[1] Songtao Xue, et al. Design, Synthesis, and Biological Evaluation of Novel Hybrids Containing Dihydrochalcone as Tyrosinase Inhibitors to Treat Skin Hyperpigmentation. J Med Chem. 2023 Apr 13;66(7):5099-5117. DOI:10.1021/acs.jmedchem.3c00012

Supplier

MQ (shanghai) Pharmaceuticals Co., Ltd.

Telephone 13761635123

Websitehttp://www.linyuepharm.com/

Bide Pharmatech Ltd.

Telephone400-1647117 13681763483

Websitehttps://www.bidepharm.com/

TargetMol Chemicals Inc.

Telephone 15002134094

Websitehttps://www.targetmol.cn/

Hefei Molybdenum Kai Pharmaceutical Technology Co., Ltd

Telephone18001872185; 18001872185

Websitehttp://www.yxjchem.com/

Compound Net Biotechnology Inc.

Telephone 15266686121

Websitehttps://www.reactiongpt.com/

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