633-47-6

Cropropamide,Geigy (Novartis)

Cropropamide, is the main component of the drug Prethcamide, which is a respiratory stimulant.

ChEBI: Cropropamide is an organonitrogen compound and an organooxygen compound. It is functionally related to an alpha-amino acid.

2-Chlorbutiric acid dimethyl amide are dissolved in absolute benzene and heated to 110°C with propylamine in the autoclave. After cooling the propylamine hydrochloride is filtered off, then the benzene solution is treated with water and freed from any dissolved propylamine hydrochloride by means of potassium lye. After distillation of the benzene the 2-propylaminobutyric acid dimethyl amide is rectified in vacuum.
2-Propylaminobutyric acid dimethyl amide is dissolved in benzene and while cooling, crotonic acid chloride is added and mixed. Then, reaction mixture is filtered and freed from benzene to give 2-(N-propyl-crotonylamido)butyric acid dimethyl amide, melting point 128°-130°C.

Respiratory stimulant