63053-14-5

AI-4-57 Hydrochloride is a ligand to the CBF? portion of the CBF?-SMMHC fusion protein. AI-4-57 Hydrochloride inhibits its binding to the Runt domain of RUNX proteins, and is also a modest potency inhibitor of the binding of wildtype CBF? to the RUNX1 Runt domain.