6286-09-5

NSC10010 is a potent growth inhibitor for gammaherpesvirus-associated B-lymphomas that acts through activation of both the NF-κB and c-Myc-mediated signaling pathways.

NSC10010 hydrochloride inhibits gammaherpesvirus associated B-lymphomas growth through activation of NF-kB and c-Myc-mediated signaling pathways. NSC10010 hydrochloride induces necrotic cell death in gammaherpesvirus infected B-cells. NSC10010 hydrochloride is also an inhibitor of Mtb ClpC1 ATPase[1][2].

[1] Dzeng RK, et al. Small molecule growth inhibitors of human oncogenic gammaherpesvirus infected B-cells. Mol Oncol. 2015 Feb;9(2):365-76. DOI:10.1016/j.molonc.2014.09.006
[2] Amritansh Bhanot, et al. Discovery of small molecule inhibitors of Mycobacterium tuberculosis ClpC1: SAR studies and antimycobacterial evaluation. Results in Chemistry. Volume 5, January 2023, 100904.