ChemicalBook CAS DataBase List 62732-44-9

62732-44-9

Name	2,3,5,6,7,8-HEXAHYDRO-1H-CYCLOPENTA[B]QUINOLIN-9-YLAMINE
CAS	62732-44-9
EINECS(EC#)	676-166-9
Molecular Formula	C12H16N2
MDL Number	MFCD00618424
Molecular Weight	188.27
MOL File	62732-44-9.mol

Synonyms

Takinocrine Brn 0475930 MFCD11052605 AKOS MSC-0106 AURORA KA-7699 Unii-cv71vtp0vn CBI-BB ZERO/005050 8-Hexahydro-1H-cyclopenta[b]quinolin-9-ylaMine 2,3,5,6,7,8-Hexahydro-1H-cyclopenta[b]quinolin-9- 1H,2H,3H,5H,6H,7H,8H-Cyclopenta[b]quinolin-9-amine 2,3,5,6,7,8-Hexahydro-1H-cyclopenta[b]quinolin-9-amine 9-AMINO-2,3,5,6,7,8-HEXAHYDRO-1H-CYCLOPENTA[B]QUINOLINE 1H-Cyclopenta(B)quinolin-9-amine, 2,3,5,6,7,8-hexahydro- 2,3,5,6,7,8-HEXAHYDRO-1H-CYCLOPENTA[B]QUINOLIN-9-YLAMINE 9-Amino-2,3,5,6,7,8-hexahydro-1H-cyclopentaxinolina monohydrate 2,3,5,6,7,8-hexahydro-1H-cyclopenta[b]quinolin-9-amine hydrochloride 2,3,5,6,7,8-Hexahydro-9-amino-1H-cyclopenta(b)quinoline hydrochloride 2,3,5,6,7,8-hexahydro-1H-cyclopenta[b]quinolin-9-ylamine hydrochloride 2,3,5,6,7,8-hexahydro-1H-cyclopenta[b]quinolin-9-amine(SALTDATA: HCl H2O) 9-Amino-2,3,5,6,7,8-hexahydro-1H-cyclopenta(b)quinoline monohydrochloride 2,3,5,6,7,8-hexahydro-1H-cyclopenta[b]quinolin-9-amine hydrochloride hydrate 1H-Cyclopenta(b)quinoline, 2,3,5,6,7,8-hexahydro-9-amino-, monohydrochloride

Chemical Properties

Melting point	202-203 °C(Solv: methanol (67-56-1); water (7732-18-5))
Boiling point	368.0±42.0 °C(Predicted)
density	1.170±0.06 g/cm3(Predicted)
storage temp.	-20°C
solubility	DMF: 25 mg/ml,DMSO: 25 mg/ml,DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml
form	A solid
pka	10.88±0.20(Predicted)
color	White to off-white

Safety Data

Hazard Codes	Xi
Hazard Note	Irritant

Hazard Information

Uses

Ipidacrine is used in biological studies as a possible treatment of toxic cognitive disorders.

Definition

ChEBI: 2,3,5,6,7,8-hexahydro-1H-cyclopenta[b]quinolin-9-amine is an aminoquinoline.

in vivo

Ipidacrine (1 mg/kg, p.o., repeated and a single dose for 5 days) by repeated administration has more potent antiamnesic effects than by single administration in induced by nucleus basalis of meynert (NBM) induced rats^[1].
Ipidacrine (10 mg/kg p.o., a single dose) significantly decreases spontaneous movements, which is more selective as an antiamnesic than either Tacrine (HY-111338) and E-2020 (HY-B0034) in rats^[1].
Ipidacrine (6.7 mg/kg, intragastrically, daily for 14 days) leads to statistically more efficient evolving of intracavernous pressure (ICPmax)/maxipressure (MAP) compared with control group in Streptozotocin (STZ) (HY-13753)-induced diabetic rats^[3].

Animal Model:	Rats^[1]
Dosage:	1 mg/kg
Administration:	p.o., repeated and a single dose for 5 days
Result:	The repeated administration of ipidacrine improved amnesia induced by nucleus basalis of meynert (NBM) lesions in the passive avoidance task in rats.

Animal Model:	Rats^[1]
Dosage:	3, 10, 30 mg/kg
Administration:	p.o., a single dose
Result:	Decreased pupil size and increased salivation at 3 mg/kg, decreased spontaneous movements at 10 mg/kg and decreased body temperature and induced tremor at 30 mg/kg in rats.

Animal Model:	Rats with streptozotocin (STZ) (HY-13753) induced diabetes mellitus-induced erectile dysfunction (DMED)^[1]
Dosage:	6.7 mg/kg
Administration:	crushed, suspended in 1% starch solution and administered intragastrically daily for 14 days
Result:	Ipidacrine was as effective as sildenafil and could significantly improve DMED symptoms.

storage

-20°C

Spectrum Detail

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