62595-74-8

3-Bromopiperidin-2,6-dione was in reaction with sodium saccharin to synthesize glutarimides derivatives to observe their activities against Ehrlich ascites carcinoma in Swiss albino mice.A thalidomide analog (I) was prepd. from 2,??3-??dihydro-??3-??thioxo-??1H-??isoindol-??1-??one and 3-??Bromo-??2,??6-??Piperidinedione.

A solution of piperidine-2,6-dione (2.00 g) and liquid bromine (2.82 g, 0.90 mL, 17.7 mmol) in chloroform (15 mL) was slowly added to a 48-mL pressure-resistant glass reaction vessel fitted with a Teflon screw cap. The reaction mixture was heated to 110 d