62224-19-5

Methyl 5-Bromo-2-thiophenecarboxylate is used as a reagent in the synthesis of trisubstituted isoxazole derivatives which are novel nonsteroidal antagonists of Farnesoid X Receptor (FXR). FXR plays an important role in regulation of cholesterol, lipid and glucose metabolism.

Journal of Medicinal Chemistry, 35, p. 1109, 1992 DOI: 10.1021/jm00084a016