6141-13-5

2-chloroquinazoline is found to act as a versatile building block for the direct introduction of the 2-quinazolinyl moiety.

(1) ortho-aminobenzoic acid reacts with potassium cyanate to generate 2,4-quinazoline diones; and (2) the 2,4-quinazoline diones and a chlorinating agent undergo a chlorination reaction to generate the 2,4-dichloroquinazoline.