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Solasodine (25-100?mg/kg; intraperitoneal injection; once) hydrochloride treatment significantly delays latency of hind limb tonic extensor (HLTE) phase in the PCT-induced convulsions. And significantly potentiates Thiopental-provoked sleep in a dose-dependent manner. Solasodine hydrochloride has anticonvulsant and CNS depressant activities^[2].
Solasodine (375 μM; i.c.v.; for 2 weeks) hydrochloride treatment results a significant increase in bromodeoxyuridine uptake by cells of the ependymal layer, subventricular zone, and cortex that co-localized with doublecortin immunostaining. Solasodine hydrochloride treatment in rats results in a dramatic increase in expression of the cholesterol- and drug-binding translocator protein in ependymal cells^[1].