Chemical Properties
Crystalline Solid
Uses
antihypertensive, diuretic, activates K channels and AMPA receptors
Uses
Diagnostic aid (radiopaque medium-cholecystographic).
Hazard
Toxic by ingestion.
Originator
Cholografin,Squibb,US,1954
Definition
ChEBI: Adipiodone is an organoiodine compound that is 3-amino-2,4,6-triiodobenzoic acid in which one of the amino hydrogens is substituted by a 6-(3-carboxy-2,4,6-triiodoanilino)-6-oxohexanoyl group. It is a water-soluble radiographic contrast media for cholecystography and intravenous cholangiography. It has a role as a radioopaque medium. It is an organoiodine compound, a member of benzoic acids and a secondary carboxamide. It is a conjugate acid of an adipiodone(2-).
Manufacturing Process
125 g of 2,4,6-triiodo-3-amino benzoic acid are dissolved in 250 cc of
chlorobenzene and 15 g of adipic acid dichloride are added at a temperature
between 110° and 130°C drop by drop to the solution. After evolution of
hydrochloric acid (about 2 to 3 hours) has ceased, the precipitated crude
adipic acid di-(3-carboxy-2,4,6-triiodo anilide) of the above formula is filtered
hot with suction, washed with chlorobenzene, extracted by boiling with
methanol and, for purification, dissolved in an amount of methanolic caustic
soda solution required for neutralization, filtered with charcoal, and
precipitated with dilute hydrochloric acid. Yield: 82.3 g, MP 306° to 308°C
(with decomposition).
Brand name
Pharmaceutic necessity for Iodipamide
Meglumine [Injection]. Cholografin (Bristol-Myers
Squibb).
Therapeutic Function
Diagnostic aid (radiopaque medium)
