59433-50-0

(±)-N-(tert-Butoxycarbonyl)proline is a useful reagent for the enantiospecific preparation of functionalized hindered triazolopyridinones.

To a 100 ml round bottom flask was added L-proline 1a (3.0 g, 26.06 mmol), sodium hydroxide (1.2 g, 28.66 mmol) and tert-butanol/water (20 ml/20 ml), respectively. Di-tert-butyl dicarbonate (6.3 g, 28.66 mmol) was slowly added to the reaction system under