58743-78-5

623-00-7

22237-13-4

58743-78-5

General procedure for the synthesis of 4-ethoxy-4'-cyanobiphenyl from 4-bromobenzonitrile and 4-ethoxyphenylboronic acid: in typical experiments, a mixture of aryl bromide (0.50 mmol), phenylboronic acid (0.55 mmol), K2CO3 (1.5 mmol), 0.2 mol% of ligand, and 1 mol% of PdCl2(CH3CN)2 in 1.5 mL of ethanol was stirred. The reaction was carried out in air at 50 °C for 1.5 hours. Subsequently, the solvent ethanol was completely removed under vacuum at 0.09 MPa and 45 °C to give the crude product. Finally, the target product was isolated and purified by silica gel column chromatography.