587-26-8

Treatment of hyperphosphatae mia in patients with end stage renal disease.

Fosrenol (Shire).

Notclassified

#N/A

Potentially hazardous interactions with other drugs Antibacterials: possibly reduces absorption of quinolones - give at least 2 hours before or 4 hours after lanthanum. Antifungals: absorption of ketoconazole reduced - give at least 2 hours apart. Antimalarials: absorption of chloroquine and hydroxychloroquine possibly reduced - give at least 2 hours apart. Thyroid hormones: reduces absorption of levothyroxine - give at least 2 hours apart

Lanthanum carbonate is poorly absorbed from the gastrointestinal tract, with an absolute oral bioavailability of less than 1%. The small fraction that is absorbed is more than 99% bound to plasma proteins and is widely distributed in the tissues, particularly the bones, the liver, and the gastrointestinal tract. Lanthanum is not metabolised. It is excreted mainly in the faeces with only around 0.000031% of an oral dose excreted via the urine in healthy subjects (renal clearance approximately 1 mL/ min, representing <2% of total plasma clearance)