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ICA 069673 is a heteromeric K_v7 channel activator. It is selective for K_v7.2/7.3 over K_v7.3/7.5 (EC₅₀s = 0.69 and 14.3 μM, respectively) and also activates K_v7.4, K_v7.5, and heteromeric K_v7.4/7.5 channels in a dose-dependent manner. ICA 069673 has no activity against hERG, Na_v1.5, and K_v7.1 cardiac ion channels (IC₅₀s = >30 μM). Oral administration of ICA 069673 increases latency to first tonic-clonic seizure in the rat maximal electroshock and pentylentetrazol-induced seizure models (ED₅₀s = 1.5 and <1 mg/kg, respectively). Formulations containing ICA 069673 are under clinical investigation for the treatment of epilepsy.

ICA-069673 is a KCNQ2/Q3 potassium channel activator. ICA-069673 demonstrates greater selectivity for KV7.2/7.3 over KV7.3/KV7.5, with EC50s of 0.69 μM and 14.3 μM, respectively. ICA-069673 inhibits spontaneous phasic and nerve-evoked contractions in guinea pig detrusor smooth muscle (DSM). ICA-069673 also decreases the global intracellular Ca(2+) concentration in DSM cells[1][2].

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[1] Provence A, et al. The Novel KV7.2/KV7.3 Channel Opener ICA-069673 Reveals Subtype-Specific Functional Roles in Guinea Pig Detrusor Smooth Muscle Excitability and Contractility. J Pharmacol Exp Ther. 2015 Sep;354(3):290-301. DOI:10.1124/jpet.115.225268