5731-01-1

White or pale brown solid

Dichloromethane was added to Aluminium chloride. The mixture was stirred and cooled to 5 °C in a salt/ice bath. Acetyl chloride was quickly added through a dropping funnel and cooled to ? 3 °C to give a transparent yellow solution. Solid 4-bromobiphenyl was added in small amounts and stirred; wait for ? an hour, then add more. The mixture was stirred for ten hours, rising to 15 °C. The mixture was poured into a bucket of ice /37 percent HCl to destroy the aluminum chloride, then transferred to a separatory funnel and extracted into DCM. Then, the mixture was washed twice with water to destroy HCl. Again, it was washed with 10 percent NaOH and water. The collected DCM layer was dried over magnesium sulfate, mostly filtered by gravity. The solvent was removed in vacuo, and the residue was re-crystallized through ethanol to yield 4-Acetyl-4'-bromobiphen