ChemicalBook CAS DataBase List 56486-94-3

56486-94-3

Name	Steppogenin
CAS	56486-94-3
Molecular Formula	C15H12O6
MDL Number	MFCD20274687
Molecular Weight	288.25
MOL File	56486-94-3.mol

Chemical Properties

solubility	Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form	Powder
color	White to off-white
InChI	InChI=1S/C15H12O6/c16-7-1-2-9(10(18)3-7)13-6-12(20)15-11(19)4-8(17)5-14(15)21-13/h1-5,13,16-19H,6H2/t13-/m0/s1
InChIKey	QBLQLKNOKUHRCH-ZDUSSCGKSA-N
SMILES	[C@H]1(C2=CC=C(O)C=C2O)OC2=CC(O)=CC(O)=C2C(=O)C1

Safety Data

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338

Hazard Information

Uses

Steppogenin is a potent inhibitor of HIF-1α and DLL4, with IC50 values of 0.56 and 8.46 μM, respectively. Steppogenin can be sued for the research of angiogenic diseases, such as those involving solid tumors[1].

in vivo

Steppogenin (2 mg/kg, IP, once) inhibits tumor growth and angiogenesis^[1].
Steppogenin (2 mg/kg, IP, once) shows the highest distribution to the liver and spleen (25.5-fold and 9.74-fold AUC ratio, respectively) with significantly higher T_1/2^[1].
Pharmacokinetic Parameters of Steppogenin in male C57BL/6 J mice^[1].

	C_max (ng/mL)	T_max (h)	T_1/2 (h)	AUC_8h (ng/mL?h)	AUC_∞ (ng/mL?h)	AUC ratio
Plasma	448 ± 113	0.25	0.49 ± 0.14	283 ± 98.9	284 ± 97.8	1
Tumor	635 ± 114	0.3 ± 0.1	1.87 ± 0.87	1078 ± 494	1252 ± 547	4.58
Liver	4319 ± 1063	0.25	1.72 ± 0.26	6733 ± 1300	6967 ± 1200	25.5
Lung	521 ± 181	0.25	0.36 ± 0.12	261 ± 96.1	280 ± 106	1.02
Heart	285 ± 15.2	0.25	0.2	107 ± 44.3	176.9	0.65
Kidney	1225 ± 463	0.25	0.33 ± 0.01	628 ± 234	624.7 ± 238	2.35
Spleen	6110 ± 2954	0.25	0.47 ± 0.01	2443 ± 1155	2663 ± 1289	9.74
Brain	309 ± 95.7	0.25	1.36 ± 0.46	191 ± 67	241 ± 75.4	0.88

Animal Model:	C57BL/6 J mice (6-week-old, male, Lewis lung carcinoma (LLC) allograft tumor model)^[1]
Dosage:	2 mg/kg
Administration:	IP, once
Result:	Significantly suppressed tumor growth.

Animal Model:	C57BL/6 J mice (6-week-old, male, Lewis lung carcinoma (LLC) allograft tumor model)^[1]
Dosage:	2 mg/kg
Administration:	IP, once (Pharmacokinetic Analysis)
Result:	Showed the highest distribution to the liver and spleen (25.5-fold and 9.74-fold AUC ratio, respectively) with significantly higher T_1/2. may not be accumulated even in the highly distributed tissues after the repeated administration of steppogenin.

target

Tyrosinase

References

[1] Cha S, et al. Steppogenin suppresses tumor growth and sprouting angiogenesis through inhibition of HIF-1α in tumors and DLL4 activity in the endothelium. Phytomedicine. 2023 Jan;108:154513. DOI:10.1016/j.phymed.2022.154513

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