55576-66-4

White crystalline powder, easily soluble in methanol and ethyl acetate, almost insoluble in water, derived from Agrimony.

Agrimol B, a polyphenol, is an orally active and potent SIRT1 activator. Agrimol B shows anti-adipogenic and anticancer activity. Agrimol B shows antibacterial activity against plant pathogens. Agrimol B dramatically inhibits 3T3-L1 adipocyte differentiation by reducing PPARγ, C/EBPα, FAS, UCP-1, and apoE expression. The action of Agrimol B on the cancer cells is likely derived from its effect on c-MYC, SKP2 and p27[1][2][3].

Agrimol B, a polyphenol derivative isolated from Agrimony, inhibits adipogenesis, induces the translocation and expression of SIRT1, and reduces the expression of PPARγ.

PPAR | Antifection

SIRT1; PPARγ

[1] Agrimol B, et al. Agrimol B suppresses adipogenesis through modulation of SIRT1-PPAR gamma signal pathway. Biochem Biophys Res Commun. 2016 Aug 26;477(3):454-60. DOI:10.1016/j.bbrc.2016.06.078
[2] Hnit SST, et al. Agrimol B present in Agrimonia pilosa Ledeb impedes cell cycle progression of cancer cells through G0 state arrest. Biomed Pharmacother. 2021 Sep;141:111795. DOI:10.1016/j.biopha.2021.111795
[3] Chun S B, et al. Antibacterial Activities against Plant Pathogens and Identification of Agrimol B from Agrimonia pilosa LEDEB[J]. ?????? ?10? 3?, 2006, 10(3):230-236.