5465-86-1

ML-204 selectively blocks transient receptor potential canonical 4 (TRPC4) channels (IC₅₀s = 0.96 and 2.6 μM in fluorescent and electrophysiological assays, respectively). It exhibits 19-fold selectivity against TRPC6 and 9-fold selectivity against TRPC5 and does not affect TRPV1, TRPV3, TRPA1, or TRPM8 channels at concentrations up to 22 μM.

4-Methyl-2-(1-piperidinyl)-quinoline is a potent inhibitor of TRPC4 channels, responsible for various stimulation, muscle response due to interaction with the environment.

ML204 is a potent and selective TRPC4 channel inhibitor.

TRPC4; TRPC5

Store at +4°C

[1] ERIKO MICHISHITA. SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin[J]. Nature, 2008, 452 7186: 492-496. DOI: 10.1038/nature06736