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54504-70-0
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Identification
Name
ETOFYLLINE CLOFIBRATE
CAS
54504-70-0
Synonyms
duolip
ml1024
Theofibrate
etofyllinclofibrat
etofyllinclofibrate
ETOFYLLINE CLOFIBRATE
Etofylline cIofibrate
ETOFYLLINE CLOFIBRATE USP/EP/BP
yl-2,6-dioxo-7h-purin-7-yl)ethylester
1-(7-theophyllinyl)-2-ethyl(2-(p-chlorophenoxy)isobutyrate)
1-(theophyllin-7-yl)-aethyl-22-(p-chlorphenoxy)-2-methylpropionat
1-(theophyllin-7-yl)-ethyl-22-(p-chlorophenoxy)-2-methylpropionate
propionicacid,2-(4-chlorophenoxy)-2-methyl-,2-(1,2,3,6-tetrahydro-1,3-dimeth
2-(1,3-dimethyl-2,6-dioxopurin-7-yl)ethyl 2-(4-chlorophenoxy)-2-methylpropanoate
2-(4-Chlorophenoxy)-2-methylpropionic acid 2-(1,2,3,6-tetrahydro-1,3-dimethyl-2,6-dioxo-7H-purin-7-yl)ethyl ester
2-(4-Chlorophenoxy)-2-methylpropionic acid [2-(1,2,3,6-tetrahydro-1,3-dimethyl-2,6-dioxo-7H-purin-7-yl)ethyl] ester
Propanoic acid, 2-(4-chlorophenoxy)-2-methyl-, 2-(1,2,3,6-tetrahydro-1,3-dimethyl-2,6-dioxo-7H-purin-7-yl)ethyl ester
EINECS(EC#)
259-191-6
Molecular Formula
C19H21ClN4O5
MDL Number
MFCD01695637
MOL File
54504-70-0.mol
Molecular Weight
420.85
ETOFYLLINE CLOFIBRATE
CAS
54504-70-0
Synonyms
duolip
ml1024
Theofibrate
etofyllinclofibrat
etofyllinclofibrate
ETOFYLLINE CLOFIBRATE
Etofylline cIofibrate
ETOFYLLINE CLOFIBRATE USP/EP/BP
yl-2,6-dioxo-7h-purin-7-yl)ethylester
1-(7-theophyllinyl)-2-ethyl(2-(p-chlorophenoxy)isobutyrate)
1-(theophyllin-7-yl)-aethyl-22-(p-chlorphenoxy)-2-methylpropionat
1-(theophyllin-7-yl)-ethyl-22-(p-chlorophenoxy)-2-methylpropionate
propionicacid,2-(4-chlorophenoxy)-2-methyl-,2-(1,2,3,6-tetrahydro-1,3-dimeth
2-(1,3-dimethyl-2,6-dioxopurin-7-yl)ethyl 2-(4-chlorophenoxy)-2-methylpropanoate
2-(4-Chlorophenoxy)-2-methylpropionic acid 2-(1,2,3,6-tetrahydro-1,3-dimethyl-2,6-dioxo-7H-purin-7-yl)ethyl ester
2-(4-Chlorophenoxy)-2-methylpropionic acid [2-(1,2,3,6-tetrahydro-1,3-dimethyl-2,6-dioxo-7H-purin-7-yl)ethyl] ester
Propanoic acid, 2-(4-chlorophenoxy)-2-methyl-, 2-(1,2,3,6-tetrahydro-1,3-dimethyl-2,6-dioxo-7H-purin-7-yl)ethyl ester
EINECS(EC#)
259-191-6
Molecular Formula
C19H21ClN4O5
MDL Number
MFCD01695637
MOL File
54504-70-0.mol
Molecular Weight
420.85
Chemical Properties
Melting point
133-135°
density
1.3758 (rough estimate)
refractive index
1.6500 (estimate)
133-135°
density
1.3758 (rough estimate)
refractive index
1.6500 (estimate)
Hazard Information
Originator
Duolip,Merckle,W. Germany,1981
Uses
Duolip (L. Merckle, Germany).
Manufacturing Process
107.3 g (0.5 mol) 2-(p-chlorophenoxy)isobutyric acid and 56.0 g (0.25 mol) 7-hydroxyethyltheophylline were suspended together in 250 ml xylene. They were heated together for 15 hours in a water separator following the addition of 1.5 g p-toluenesulfonic acid. The solution was next agitated with dilute sodium bicarbonate solution (0.5 mol NaHCO3), water washed and evaporated in a rotary evaporator.
The residue was then crystallized from isopropanol, yielding 58.0 g (55% yield) of 1-(7-theophyllinyl)-2-ethyl[2-(p-chlorophenoxy)-isobutyrate] . The compound had a melting point of 131°C to 132°C.
Therapeutic Function
Antihyperlipidemic
Duolip,Merckle,W. Germany,1981
Uses
Duolip (L. Merckle, Germany).
Manufacturing Process
107.3 g (0.5 mol) 2-(p-chlorophenoxy)isobutyric acid and 56.0 g (0.25 mol) 7-hydroxyethyltheophylline were suspended together in 250 ml xylene. They were heated together for 15 hours in a water separator following the addition of 1.5 g p-toluenesulfonic acid. The solution was next agitated with dilute sodium bicarbonate solution (0.5 mol NaHCO3), water washed and evaporated in a rotary evaporator.
The residue was then crystallized from isopropanol, yielding 58.0 g (55% yield) of 1-(7-theophyllinyl)-2-ethyl[2-(p-chlorophenoxy)-isobutyrate] . The compound had a melting point of 131°C to 132°C.
Therapeutic Function
Antihyperlipidemic
Safety Data
Toxicity
LD50 in mice, rats, dogs (g/kg): 11.7, 17.0, >10.0 orally (Metz et al.)
LD50 in mice, rats, dogs (g/kg): 11.7, 17.0, >10.0 orally (Metz et al.)
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