Supplier Related Products Identification Chemical Properties Hazard Information Safety Data
ChemicalBook >  CAS DataBase List  > 54504-70-0

54504-70-0

Supplier Related Products Identification Chemical Properties Hazard Information Safety Data

Product Image

Identification

Name
ETOFYLLINE CLOFIBRATE
CAS
54504-70-0
Synonyms
duolip
ml1024
Theofibrate
etofyllinclofibrat
etofyllinclofibrate
ETOFYLLINE CLOFIBRATE
Etofylline cIofibrate
ETOFYLLINE CLOFIBRATE USP/EP/BP
yl-2,6-dioxo-7h-purin-7-yl)ethylester
1-(7-theophyllinyl)-2-ethyl(2-(p-chlorophenoxy)isobutyrate)
1-(theophyllin-7-yl)-aethyl-22-(p-chlorphenoxy)-2-methylpropionat
1-(theophyllin-7-yl)-ethyl-22-(p-chlorophenoxy)-2-methylpropionate
propionicacid,2-(4-chlorophenoxy)-2-methyl-,2-(1,2,3,6-tetrahydro-1,3-dimeth
2-(1,3-dimethyl-2,6-dioxopurin-7-yl)ethyl 2-(4-chlorophenoxy)-2-methylpropanoate
2-(4-Chlorophenoxy)-2-methylpropionic acid 2-(1,2,3,6-tetrahydro-1,3-dimethyl-2,6-dioxo-7H-purin-7-yl)ethyl ester
2-(4-Chlorophenoxy)-2-methylpropionic acid [2-(1,2,3,6-tetrahydro-1,3-dimethyl-2,6-dioxo-7H-purin-7-yl)ethyl] ester
Propanoic acid, 2-(4-chlorophenoxy)-2-methyl-, 2-(1,2,3,6-tetrahydro-1,3-dimethyl-2,6-dioxo-7H-purin-7-yl)ethyl ester
EINECS(EC#)
259-191-6
Molecular Formula
C19H21ClN4O5
MDL Number
MFCD01695637
MOL File
54504-70-0.mol
Molecular Weight
420.85

Chemical Properties

Melting point 
133-135°
density 
1.3758 (rough estimate)
refractive index 
1.6500 (estimate)

Hazard Information

Originator
Duolip,Merckle,W. Germany,1981
Uses
Duolip (L. Merckle, Germany).
Manufacturing Process
107.3 g (0.5 mol) 2-(p-chlorophenoxy)isobutyric acid and 56.0 g (0.25 mol) 7-hydroxyethyltheophylline were suspended together in 250 ml xylene. They were heated together for 15 hours in a water separator following the addition of 1.5 g p-toluenesulfonic acid. The solution was next agitated with dilute sodium bicarbonate solution (0.5 mol NaHCO3), water washed and evaporated in a rotary evaporator.
The residue was then crystallized from isopropanol, yielding 58.0 g (55% yield) of 1-(7-theophyllinyl)-2-ethyl[2-(p-chlorophenoxy)-isobutyrate] . The compound had a melting point of 131°C to 132°C.
Therapeutic Function
Antihyperlipidemic

Safety Data

Toxicity
LD50 in mice, rats, dogs (g/kg): 11.7, 17.0, >10.0 orally (Metz et al.)
SupplierMore

Related Products

54965-21-8 53643-48-4 63585-09-1 28395-03-1 16816-67-4 1882-26-4 882-09-7 86-88-4 519-37-9 18995-35-2 3307-39-9