Clofibric acid is a peroxisome proliferator-activated receptor α (PPARα) agonist (EC
50 = 50 μM in a transactivation assay) and the active metabolite of clofibrate (Item No.
10956).
1 It is formed from clofibrate by tissue and serum esterases.
2 Dietary administration of clofibric acid (0.067-0.22%) reduces serum cholesterol, phospholipid, and triglyceride levels in rats.
3 It decreases glutamate oxaloacetate transaminase (GOT) levels and increases glutamate pyruvate transaminase (GPT) and lactate dehydrogenase (LDH) levels, markers of xenobiotic stress, in the plasma of carp (
C. carpio) when administered in tank water at a concentration of 10 μg/L.
4 Clofibric acid has been found in wastewater effluent.
5 
