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Mitragynine pseudoindoxyl (Item No. 20033) is an analytical reference standard categorized as an opioid.1,2 Mitragynine pseudoindoxyl has analgesic activity in mice without inducing the development of opioid-induced hyperalgesia.2 It induces physical dependence in mice but reduces signs of withdrawal in morphine-dependent mice administered naloxone. This product is intended for research and forensic applications.WARNING This product is not for human or veterinary use.

[1] ANDRÁS VÁRADI. Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2[J]. Journal of Medicinal Chemistry, 2016, 59 18: 8381-8397. DOI: 10.1021/acs.jmedchem.6b00748
[2] LISA L WILSON. Kratom Alkaloids, Natural and Semi-Synthetic, Show Less Physical Dependence and Ameliorate Opioid Withdrawal.[J]. Cellular and Molecular Neurobiology, 2021, 41 5: 1131-1143. DOI: 10.1007/s10571-020-01034-7