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Paynantheine (Item No. 21841) is an alkaloid of the herbal drug M. speciosa (also known as kratom). Kratom (mitragynine; Item Nos. 11151 | 18567) has opioid-like and stimulant effects, and paynantheine can be detected in urine after kratom ingestion. Paynantheine blocks the delayed-rectifier potassium current in human induced pluripotent stem cell-derived cardiomyocytes (IC₅₀ = 2.47 μM), suggesting that it may have cardiotoxic effects. This product is intended for research and forensic applications.

(+)-Paynantheine is a potential psychoactive alkaloid found in kratom.

5-HT_1A Receptor; 5-HT_2B Receptor

[1] ANIKA A. PHILIPP . Metabolism studies of the Kratom alkaloids mitraciliatine and isopaynantheine, diastereomers of the main alkaloids mitragynine and paynantheine, in rat and human urine using liquid chromatography–linear ion trap-mass spectrometry[J]. Journal of Chromatography B, 2011, 879 15: Pages 1049-1055. DOI: 10.1016/j.jchromb.2011.03.005
[2] FRANCISCO LEóN. Activity of Mitragyna speciosa (“Kratom”) Alkaloids at Serotonin Receptors[J]. Journal of Medicinal Chemistry, 2021, 64 18: 13510-13523. DOI: 10.1021/acs.jmedchem.1c00726
[3] ANNA M GUTRIDGE. G protein-biased kratom-alkaloids and synthetic carfentanil-amide opioids as potential treatments for alcohol use disorder.[J]. British Journal of Pharmacology, 2020, 177 1: 1497-1513. DOI: 10.1111/bph.14913
[4] KYUNHEE KIM. Biosynthesis of Kratom Opioids[J]. bioRxiv?: the preprint server for biology, 2022, 11 1. DOI: 10.1101/2022.12.25.521902