52436-88-1

beta-nor-Lapachone functions as an antibiofilm agent and adjuvant on the antifungal therapy related to resistant infections caused by C. glabrata.

β-Nor-lapachone is a Candida glabrata antibiofilm agent. β-Nor-lapachone can stimulate ROS production, inhibits efflux activity, adhesion, biofilm formation and the metabolism of mature biofilms of Candida glabrata. β-Nor-lapachone has antifungal activity[1].

[1] Clemente de Moraes D, et al. Effects of β-lapachone and β-nor-lapachone on multidrug efflux transporters and biofilms of Candida glabrata. Bioorg Med Chem. 2022;63:116749. DOI:10.1016/j.bmc.2022.116749