521062-92-0

O-2172, a carbacyclic analog, is a DAT inhibitor, with IC50 values of 47 nM and 7000 nM for DAT and SERT, respectively[1].

[1] Peter C Meltzer, et al. Synthesis and evaluation of dopamine and serotonin transporter inhibition by oxacyclic and carbacyclic analogues of methylphenidate. J Med Chem. 2003 Apr 10;46(8):1538-45. DOI:10.1021/jm0205292