51020-86-1

Licarin A is found in plants such as Aristolochia taliscana , Machilus thunbergii and Myristica fragrans , which are used as spices and in folk medicines for nervous and digestive disorders. It also exhibits anti-inflammatory effects.
Licarin A (5-20 μM) reduces TNF-α and prostaglandin D2 (PGD2) secretion via the inhibition of PKCα/βII and p38 MAPK pathways. Licarin A treatment tends to reduce phosphorylated PKCα/βII and p38 MAPK protein levels.