510-77-0

Name GALANTHAMINONE
CAS 510-77-0
Molecular Formula C17H19NO3
MDL Number MFCD08063719
Molecular Weight 285.34
MOL File 510-77-0.mol
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Chemical Properties

Appearance White to Off-White
Melting point  175-180°C (dec.)
Boiling point  397.4±42.0 °C(Predicted)
density  1.28±0.1 g/cm3(Predicted)
storage temp.  -20°C Freezer
solubility  DMSO : 10 mg/mL (35.05 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
form  Cryst.
pka 7.84±0.20(Predicted)
color  White to off-white
InChI InChI=1S/C17H19NO3/c1-18-8-7-17-6-5-12(19)9-14(17)21-16-13(20-2)4-3-11(10-18)15(16)17/h3-6,14H,7-10H2,1-2H3/t14-,17-/m0/s1
InChIKey QENVUHCAYXAROT-YOEHRIQHSA-N
SMILES N1(C)CC2=CC=C(OC)C3O[C@]4([H])[C@@](C=CC(=O)C4)(C2=3)CC1
Uses
Narwedine is the biogenetic precursor of galanthamine, has been studied as a respiratory stimulator. It increases the amplitude and decreases the frequency of cardiac contractions and would therefore be of value in reducing blood loss during surgery. It also inhibits the action of narcotics and hypnotics, and increases the analgesic effect of morphine as well as the pharmacological effects of caffeine, carbazole, arecoline, and nicotine.

Safety Data

Symbol(GHS)  Skull and Crossbones (GHS06)
GHS06
Signal word  Danger
Hazard statements  H331-H301
Precautionary statements  P264-P270-P301+P310-P321-P330-P405-P501-P261-P271-P304+P340-P311-P321-P403+P233-P405-P501

Hazard Information

Spectrum Detail

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