ChemicalBook CAS DataBase List 5072-26-4

5072-26-4

Name	DL-BUTHIONINE-[S,R]-SULFOXIMINE
CAS	5072-26-4
EINECS(EC#)	246-685-1
Molecular Formula	C8H18N2O3S
MDL Number	MFCD00070309
Molecular Weight	222.31
MOL File	5072-26-4.mol

Chemical Properties

Appearance	White Crystalline Solid
Melting point	215 °C (dec.)(lit.)
Boiling point	382.3±52.0 °C(Predicted)
density	1.29±0.1 g/cm3(Predicted)
storage temp.	2-8°C
solubility	H₂O: 50 mg/mL, clear, colorless
form	Fluffy Powder
color	White
Usage	A potent and specific inhibitor of alpha-glutamyl cysteine synthetase
Merck	13,1520
BRN	2367136
CAS DataBase Reference	5072-26-4(CAS DataBase Reference)

Safety Data

Hazard Codes	Xi
Risk Statements	R36/37/38:Irritating to eyes, respiratory system and skin . less more
Safety Statements	S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . S36:Wear suitable protective clothing . less more
WGK Germany	3
RTECS	EK7713435
F	10
HS Code	29309090

Raw materials And Preparation Products

Hazard Information

Chemical Properties

White Crystalline Solid

Uses

DL-Buthionine-sulfoximine is suitable for use to:

examine whether the inhibition of glutathione by BSO enhances the apoptotic effect of estrogen on antihormone-resistant human breast cancer cells
investigate the effect of BSO on development of bovine embryos
inhibit GSH in several studies
investigate the effect of GSH synthesis on oocyte maturation

It may be used to inhibit GSH and evaluate the hepatotoxicity and nephrotoxicity of natural food colorants in the absence of GSH

Uses

A potent and specific inhibitor of alpha-glutamyl cysteine synthetase

Uses

Biological tool for depletion of glutathione.

Definition

ChEBI: A sulfoximide that is the sulfoximine derivative of an analogue of DL-methionine in which the S-methyl group is replaced by S-butyl.

General Description

DL-buthionine-SR-sulfoximine (BSO) is an amino acid analogue, which acts as an inhibitor of γ-glutamylcysteine synthetase. BSO increases the sensitivity of Trypanosoma cruzi to antiparasitic drugs, such as nifurtimox or benznidazole.

Biochem/physiol Actions

DL-Buthionine-sulfoximine inhibits the biosynthesis of Glutathione (GSH) in liver and other peripheral organs. It does not have any effect on GSH in the CNS. It augments the antiproliferative action of reactive oxygen species (e.g., hydrogen peroxide), and agents that indirectly cause accumulation of reactive oxygen species (e.g., 2-methoxyestradiol, which increases intracellular superoxide anion).

Spectrum Detail

Well-known Reagent Company Product Information

Supplier

J & K SCIENTIFIC LTD.

Telephone010-82848833 400-666-7788

Websitehttp://www.jkchemical.com

Meryer (Shanghai) Chemical Technology Co., Ltd.

Telephone021-61259108 18621169109

Websitehttps://www.meryer.com/cn/index/

3B Pharmachem (Wuhan) International Co.,Ltd.

Telephone821-50328103-801 18930552037

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList13285/0.htm

Chemsky（shanghai）International Co.,Ltd.

Telephone021-50135380

Websitehttp://www.shchemsky.com

Thermo Fisher Scientific

Telephone800-810-5118

Websitehttp://www.thermo.com.cn

Beijing innoChem Science & Technology Co.,Ltd.

Telephone400-810-7969 010-59572699

Websitehttp://www.inno-chem.com.cn

9ding chemical ( Shanghai) Limited

Telephone4009209199

Websitehttp://www.9dingchem.com

Shanghai Macklin Biochemical Co.,Ltd.

Telephone15221275939 15221275939

Websitehttp://www.macklin.cn

Sigma-Aldrich

Telephone021-61415566 800-8193336

Websitehttps://www.sigmaaldrich.cn

Shandong Xiya Chemical Co., Ltd.

Telephone4009903999 13395398332

Websitehttp://www.xiyashiji.com

Shanghai Chaolan Chemical Technology Center

Telephone021-QQ：65489617 15618227136

Websitehttp://www.atkchemical.com/

Beijing Jin Ming Biotechnology Co., Ltd.

Telephone010-60605840 18892239720

Websitehttp://www.jm-bio.com/

Shandong Ono Chemical Co., Ltd.

Telephone0539-6362799 20）

Websitehttp://www.onochem.com

Aikon International Limited

Telephone025-66113011 18112977050

Websitehttp://www.aikonchem.com

Beijing OKA biological technology co., LTD

Telephone010-010-010-62971590 18548936886

Websitehttp://www.bjoka-vip.com/

Nextpeptide Inc

Telephone+86-0571-81612335 +8613336028439

Websitehttp://www.nextpeptide.com/

Career Henan Chemica Co

Telephone+86-0371-86658258 +8613203830695

Websitehttps://www.coreychem.com/

DC Chemicals

Telephone021-58447131 13564518121

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList927327/0.htm

1of4

Related Products

Send Inquriy