ChemicalBook CAS DataBase List 5072-26-4

5072-26-4

Name	DL-BUTHIONINE-[S,R]-SULFOXIMINE
CAS	5072-26-4
EINECS(EC#)	246-685-1
Molecular Formula	C8H18N2O3S
MDL Number	MFCD00070309
Molecular Weight	222.31
MOL File	5072-26-4.mol

Chemical Properties

Appearance	White Crystalline Solid
Melting point	215 °C (dec.)(lit.)
Boiling point	382.3±52.0 °C(Predicted)
density	1.29±0.1 g/cm3(Predicted)
storage temp.	2-8°C
solubility	H₂O: 50 mg/mL, clear, colorless
form	Fluffy Powder
color	White
Usage	A potent and specific inhibitor of alpha-glutamyl cysteine synthetase
Merck	13,1520
BRN	2367136
CAS DataBase Reference	5072-26-4(CAS DataBase Reference)

Safety Data

Hazard Codes	Xi
Risk Statements	R36/37/38:Irritating to eyes, respiratory system and skin . less more
Safety Statements	S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . S36:Wear suitable protective clothing . less more
WGK Germany	3
RTECS	EK7713435
F	10
HS Code	29309090

Raw materials And Preparation Products

Hazard Information

Chemical Properties

White Crystalline Solid

Uses

DL-Buthionine-sulfoximine is suitable for use to:

examine whether the inhibition of glutathione by BSO enhances the apoptotic effect of estrogen on antihormone-resistant human breast cancer cells
investigate the effect of BSO on development of bovine embryos
inhibit GSH in several studies
investigate the effect of GSH synthesis on oocyte maturation

It may be used to inhibit GSH and evaluate the hepatotoxicity and nephrotoxicity of natural food colorants in the absence of GSH

Uses

A potent and specific inhibitor of alpha-glutamyl cysteine synthetase

Uses

Biological tool for depletion of glutathione.

Definition

ChEBI: A sulfoximide that is the sulfoximine derivative of an analogue of DL-methionine in which the S-methyl group is replaced by S-butyl.

General Description

DL-buthionine-SR-sulfoximine (BSO) is an amino acid analogue, which acts as an inhibitor of γ-glutamylcysteine synthetase. BSO increases the sensitivity of Trypanosoma cruzi to antiparasitic drugs, such as nifurtimox or benznidazole.

Biochem/physiol Actions

DL-Buthionine-sulfoximine inhibits the biosynthesis of Glutathione (GSH) in liver and other peripheral organs. It does not have any effect on GSH in the CNS. It augments the antiproliferative action of reactive oxygen species (e.g., hydrogen peroxide), and agents that indirectly cause accumulation of reactive oxygen species (e.g., 2-methoxyestradiol, which increases intracellular superoxide anion).

Spectrum Detail

Well-known Reagent Company Product Information

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