49764-63-8

4,5-Dibromobenzene-1,2-diamine-13C6 is a useful research chemicall.

The general procedure for the synthesis of 4,5-dibromo-o-phenylenediamine using N,N'-(4,5-dibromo-1,2-phenylene)bis(4-methylbenzenesulfonamide) as starting material was as follows: 70 mL of concentrated sulfuric acid was mixed with 35.2 g (0.058 mol) of N,N'-(4,5-dibromo-1,2-phenylene)bis(4-methylbenzenesulfonamide), and the reaction was heated to 110 °C and maintained for for 15 minutes. After completion of the reaction, the mixture was cooled to room temperature, slowly poured into ice water and neutralized with 50% aqueous sodium hydroxide. Subsequently, the precipitate precipitated was filtered, washed thoroughly with 300 mL of water, and dried to give 14.3 g (91% yield) of 4,5-dibromophthalimide, which was analyzed by HPLC to have a purity (area percent) of 97%.

[1] RSC Advances, 2018, vol. 8, # 54, p. 30761 - 30776
[2] Organic and Biomolecular Chemistry, 2012, vol. 10, # 35, p. 7045 - 7052
[3] Chemistry - A European Journal, 2017, vol. 23, # 36, p. 8644 - 8651
[4] Patent: KR2016/38052, 2016, A. Location in patent: Paragraph 0835; 0836
[5] Journal of Chemical Research, Miniprint, 1998, # 7, p. 1585 - 1594