487-58-1

White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents.

Hypaphorine is an indole alkaloid isolated from Caragana korshinskii. Hypaphorine has neurological and glucose-lowering effects. Hypaphorine prevents Lipopolysaccharides (LPS) (HY-D1056)-mediated acute lung injury (ALI) and proinflammatory response via inactivating the p38/JNK signaling pathway by upregulating DUSP1[1][2][3][4].

ChEBI: An amino acid betaine obtaine by exhaustive methylation of the alpha-amino group of L-tryptophan with concomitant deprotonation of the carboxy group.

A method for the preparation of a high-purity lenticin, characterized by the following steps: I small-leafed mallow raw materials crushed, plus acidic water immersion extraction 2 to 3 times, the extract ultrafiltration membrane ultrafiltration and then c

[1] Keller BO, et al. Hypaphorine is present in human milk in association with consumption of legumes. J Agric Food Chem. 2013 Aug 7;61(31):7654-60. DOI:10.1021/jf401758f
[2] Ding YH, et al. Hypaphorine exerts anti-inflammatory effects in sepsis induced acute lung injury via modulating DUSP1/p38/JNK pathway. Kaohsiung J Med Sci. 2021 Oct;37(10):883-893. DOI:10.1002/kjm2.12418
[3] Ditengou FA, et al. Hypaphorine from the ectomycorrhizal fungus Pisolithus tinctorius counteracts activities of indole-3-acetic acid and ethylene but not synthetic auxins in eucalypt seedlings. Mol Plant Microbe Interact. 2000 Feb;13(2):151-8. DOI:10.1094/MPMI.2000.13.2.151
[4] Chand K, et al. Major alkaloidal constituent from Impatiens niamniamensis seeds as antihyperglycemic agent. Med Chem Res 20, 1505–1508 (2011).