483-90-9

Toddalia aculeata Pers. (Rutaceae) contains, in addition to Berberine (q.v.), two closely related alkaloids. This particular base forms colourless crystals from CHC13 and is characterized as the hydrochloride monohydrate, m.p. 205-6°C; nitrate, yellow needles, m.p. 239° C (dec.) and the picrate, glancing needles, m.p. 237-8°C. Two methoxyl groups and a methylimino group have been shown to be present.

Toddalolactone is a prenylated coumarin which acts as a natural phosphodiesterase-4 inhibitor. Antiplasmodial and larvicidal agent.

Dey, Pillay., Arch. Pharm., 271,477 (1933)
Dey et al., Ind. J. Med. Res., 22,765 (1935)
Lobstein, Hesse., Bull. Sci. Pharmacol., 38, 157 (1931)