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Kayaflavone is an amentoflavone type biflavonoid. Kayaflavone has an inhibitory activity against amyloid-β42 cytotoxicity in PC-12 cells with an EC50 value of 5.29 μΜ. Kayaflavone is promising for research of Alzheimer’s disease[1].

Willow leaf loosestrife leaves crushed, weighing 20kg, with 8 times 90% methanol solution ultrasonic extraction for 30 minutes, extracted three times, the extract was concentrated under reduced pressure and added to the HZ816 macroporous resin column adso

[1] Sasaki H, et al. Inhibitory activities of biflavonoids against amyloid-β peptide 42 cytotoxicity in PC-12 cells. Bioorg Med Chem Lett. 2015 Jul 15;25(14):2831-3. DOI:10.1016/j.bmcl.2015.04.106
[2] Sun CM, et al. Selective cytotoxicity of ginkgetin from Selaginella moellendorffii. J Nat Prod. 1997 Apr;60(4):382-4. DOI:10.1021/np960608e