480463-02-3

GKA-22 is an allosteric activator of human glucokinase in the absence of glucose.

Glucokinase activator 6 (compound 9) is a potent glucokinase activator, with an EC50 of 0.09 μM. Glucokinase activator 6 can be used for type 2 diabetes (T2D) research[1].

[1] Kumari V, et al. Comparative docking assessment of glucokinase interactions with its allosteric activators. Curr Chem Genomics. 2008 Dec 30;2:76-89. DOI:10.2174/1875397300802010076