476617-51-3

Name	Bay 41-4109 (less active enantiomer)
CAS	476617-51-3
Molecular Formula	C18H13ClF3N3O2
Molecular Weight	395.76
MOL File	476617-51-3.mol

Synonyms

Bay 41-4109 (less active enantiomer) Bayer 41-4109 less active enantiomer BAY41-4109 LESS ACTIVE ENANTIOMER; BAY-41-4109 LESS ACTIVE ENANTIOMER; BAYER 41-4109 LESS ACTIVE ENANTIOMER methyl (4S)-4-(2-chloro-4-fluorophenyl)-2-(3,5-difluoropyridin-2-yl)-6-methyl-1,4-dihydropyrimidine-5-carboxylate 5-Pyrimidinecarboxylic acid, 4-(2-chloro-4-fluorophenyl)-2-(3,5-difluoro-2-pyridinyl)-1,4-dihydro-6-methyl-, methyl ester, (4S)-

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Chemical Properties

storage temp.	Store at -20°C
solubility	DMSO : ≥ 37 mg/mL (93.49 mM)
form	Solid
color	Light yellow to yellow

Hazard Information

Uses

Bay 41-4109 less active enantiomer shows less activity than Bay 41-4109. BAY 41-4109 is a potent inhibitor of human hepatitis B virus (HBV) with an IC50 of 53 nM.

in vivo

BAY 41-4109 reduces viral DNA in the liver and in the plasma dose-dependently with efficacy comparable to 3TC. BAY 41 -4109 reduces hepatitis B virus core antigen (HBcAg) in livers of HBV-transgenic mice. Pharmacokinetic studies in mice have shown rapid absorption, a bioavailability of 30% and dose-proportional plasma concentrations, about 60% in rats and dogs^[1]. BAY41-4109 inhibits virus production in vivo by a mechanism that targets the viral capsid^[2].

storage

Store at -20°C

References

[1] Weber O, et al. Inhibition of human hepatitis B virus (HBV) by a novel non-nucleosidic compound in a transgenic mouse model. Antiviral Res. 2002 May;54(2):69-78. DOI:10.1016/s0166-3542(01)00216-9
[2] Stray SJ, et al. BAY 41-4109 has multiple effects on Hepatitis B virus capsid assembly. J Mol Recognit. 2006 Nov-Dec;19(6):542-8. DOI:10.1002/jmr.801
[3] Wu GY, et al. Inhibition of hepatitis B virus replication by Bay 41-4109 and its association with nucleocapsid disassembly. J Chemother. 2008 Aug;20(4):458-67. DOI:10.1179/joc.2008.20.4.458

Supplier

Fan De(Beijing) Biotechnology Co., Ltd.

Telephone 15911056312

Websitehttp://www.bio-fount.com/

cjbscvictory

Telephone13348960310 13348960310

Websitehttps://www.weikeqi-biotech.com/

Beijing Jin Ming Biotechnology Co., Ltd.

Telephone010-60605840

Websitehttp://www.jm-bio.com/

TargetMol Chemicals Inc.

Telephone 15002134094

Websitehttps://www.targetmol.cn/

Zhejiang Huida Biotech Co., Ltd.

Telephone0571-89903022 18679456698

Websitehttps://www.huidacollection.cn

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