The general procedure for the synthesis of (R)-3-methoxypyrrolidine hydrochloride from (R)-N-Boc-3-methoxytetrahydropyrrole was as follows: tert-butyl (R)-3-methoxypyrrolidine-1-carboxylate (1100 mg, 5.47 mmol) was dissolved in 4M HCl/dioxane solution (15 mL, 60 mmol), and the reaction was stirred for 16 hours at 20 °C. After completion of the reaction, the reaction mixture was concentrated to give the crude product (1000 mg, 7.27 mmol) as an oil. The structure of the product was confirmed by 1H NMR (CDCl3, 400 MHz) with the following chemical shifts: δH= 10.10-9.39 (m, 2H), 4.13-4.04 (m, 1H), 3.51-3.35 (m, 4H), 3.31 (s, 3H), 2.24-2.12 (m, 1H), 2.08-1.95 (m, 1H) .
