4697-68-1

One of the alkaloids isolated from the leaves of Mitragyna speciosa, the structure of the base has been determined from the NMR spectrum which demonstrates that the alkaloid has a cis DIE ring junction and a conformation such that the oxindole ring deshields the ester methoxyl group.

Uncarine D is a compound extracted from Uncaria tomentosa leaves. The compounds extracted from these leaves have exhibited immunomodulating, antiinflammatory and anti-cancer activity, attributed to the presence of tetra/pentacyclic oxindole alkaloids.

ChEBI: Uncarine D is a member of indolizines.

Beckett et al., Sci. Pharm., Froc., 25th (1965)