Hazard Information
Description
Ecallantide, also known as DX-88, was approved in 2009 in the
United States for treatment of hereditary angioedema (HAE), a condition
characterized by episodic attacks of localized edema in cutaneous
and mucosal tissues. HAE results from deficiencies or disorders of C1-esterase inhibitor protein (C1-
1NH). Mutation of the gene that encodes C1-1NH causes the lack or
altered activity of the serine protease, C1-1NH. C1-1NH regulates the
kallikrein–kinin (contact activation) and complement cascade systems.
Ecallantide (DX-88) was designed to inhibit the action of
plasma kallikrein. Ecallantide is a potent and selective inhibitor of
plasma kallikrein with a Ki= 25 pM. The discovery program that
identified ecallantide used phage display technology and a library of
designed variants of the first Kunitz domain of TFPI. Ecallantide, a
60-amino acid peptide, with 3-disulfide bonds, differs from TFPI by
7-amino acids. Ecallantide has been developed as a subcutaneous
administered formulation.
Originator
Dyax Corp. (United States)
Uses
Treatment of hereditary angioedema; reduction of blood loss during cardiothoracic surgery (plasma kallikrein inhibitor).
Brand name
Kalbitor
Supplier
Wuxi Zhongkun Biochemical Technology Co., Ltd.
Telephone0510-85629785 18013409632
Websitehttp://www.reading-chemicals.com
Chengdu Youngshe Chemical Co., Ltd.
Telephone+86-17380623303 +86-17380623303
Websitehttps://shop326109856.taobao.com/
Hangzhou Peptidego Biotech Co.,Ltd.
Telephone0571-87213919
Websitehttp://www.peptidego.com
Shanghai Han-Xiang Chemical Co., Ltd.
Telephone 15971444841
Websitehttp://www.biochempartner.com.cn
Henan Alfa Chemical Co., Ltd
Telephone +8618339805032
Websitehttps://www.chemicalbook.com/manufacturer/henan-alfa-chemical-570/
Wuhan Fortuna Chemical Co., Ltd
Telephone+86-027-59207850
Websitehttp://www.fortunachem.com/
Dideu Industries Group Limited
Telephone+86-29-89586680 +86-15129568250
Websitehttps://www.dideu.com
Wuxi Helen Biotechnology Co., Ltd.,
Telephone0510-85629785 18013409632
Websitehttp://www.reading-chemicals.com
Hangzhou Go Top Peptide Biotech
Telephone0571-88211921 13355716090
Websitehttp://www.gotopbio.com/
Nanjing Yuanpeptide Biotech Co.,Ltd.
Telephone 18168071971
Websitehttp://www.yuan-peptide.com
Chengdu Jinglin Biotechnology Co., Ltd.
Telephone 17711399154
Websitehttps://www.chemicalbook.com/ShowSupplierProductsList906491/0.htm
Shaoxing Junyu Biotechnology Co., LTD
Telephone0571-88211921 15572296305
Websitehttp://www.gotopbio.com/
Hangzhou Sinoda Pharmaceutical Technology Co. LTD
Telephone0571-87213919 17306812703
Websitehttps://www.chemicalbook.com/ShowSupplierProductsList1355681/0.htm
Hangzhou Baige Pharmaceutical Technology Co. , Ltd.
Telephone0571-85350119 15888826472
Websitehttp://www.hzbaigebio.com
Shanghai HongTide Biotechnology Co.,Ltd.
Telephone 19961912513
Websitehttps://www.hongtide.com/index.php
Combio (Suzhou) Ltd.
Telephone0512-51886999 17706251929
Websitehttp://www.combiosz.com/
Zhejiang Jiekun Biotechnology Co., Ltd
Telephone0571-88211951 13735575465
Websitehttp://www.gotopbio.com/
Taiyuan Bailihengkang Biotechnology Co., Ltd
Telephone19135651983 19135651983
Websitehttp://www.blhkpharm.com/
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