ecallantide
460738-38-9 Basic informationMore
- Product Name:ecallantide
- Synonyms: ecallantide DX 88 ecallantide USP/EP/BP Cys16-Cys40 Cys32-Cys53) H-Glu-Ala-Met-His-Ser-Phe-Cys-Ala-Phe-Lys-Ala-Asp-Asp-Gly-Pro-Cys-Arg-Ala-Ala-His-Pro-Arg-Trp-Phe-Phe-Asn-Ile-Phe-Thr-Arg-Gln-Cys-Glu-Glu-Phe-Ile-Tyr-Gly-Gly-Cys-Glu-Gly-Asn-Gln-Asn-Arg-Phe-Glu-Ser-Leu-Glu-Glu-Cys-Lys-Lys-Met-Cys-Thr-Arg-Asp-OH(Disulfide bridge：Cys7-Cys57
- CAS:460738-38-9
- MF:C305H442N88O91S8
- MW:7053.82798
- EINECS:
- Mol File:460738-38-9.mol
-
USE
Ecallantide, also known as DX-88, was approved in 2009 in the
United States for treatment of hereditary angioedema (HAE), a condition
characterized by episodic attacks of localized edema in cutaneous
and mucosal tissues. HAE results from deficiencies or disorders of C1-esterase inhibitor protein (C1-
1NH). Mutation of the gene that encodes C1-1NH causes the lack or
altered activity of the serine protease, C1-1NH. C1-1NH regulates the
kallikrein–kinin (contact activation) and complement cascade systems.
Ecallantide (DX-88) was designed to inhibit the action of
plasma kallikrein. Ecallantide is a potent and selective inhibitor of
plasma kallikrein with a Ki= 25 pM. The discovery program that
identified ecallantide used phage display technology and a library of
designed variants of the first Kunitz domain of TFPI. Ecallantide, a
60-amino acid peptide, with 3-disulfide bonds, differs from TFPI by
7-amino acids. Ecallantide has been developed as a subcutaneous
administered formulation.
Lastest Price from ecallantide manufacturers
- Ecallantide
-
- US $0.00 /g
- CAS:460738-38-9
- Min. Order: 1g
- Purity: 98%min
- Supply Ability: 1000g
- 2025-01-10
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- Company Name:Chengdu Youngshe Chemical Co., Ltd.
- Tel:+86-17380623303 +86-17380623303
- Products Intro:Product Name:Ecallantide
CAS:460738-38-9
Purity:95% Package:1G; 10G; 100G - CB Index:58
- Related Information:Catalog(4809)
- Company Name:Hangzhou Peptidego Biotech Co.,Ltd.
- Tel:0571-87213919
- Products Intro:Product Name:ecallantide
CAS:460738-38-9
Purity:95% or 98% HPLC Package:1mg；5mg；10mg；50mg；100mg,1g or according to customer's detail requirement. - CB Index:58
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- Company Name:Henan Alfa Chemical Co., Ltd
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- Products Intro:CAS:460738-38-9
Purity:97%+ Package:25g; 100g; 500g; 1kg; 25kg;bulk package - CB Index:58
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- Company Name:Wuhan Fortuna Chemical Co., Ltd
- Tel:+86-027-59207850
- Products Intro:Product Name:Ecallantide
CAS:460738-38-9
Purity:98%min Package:1g - CB Index:58
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- Company Name:Dideu Industries Group Limited
- Tel:+86-29-89586680 +86-15129568250
- Products Intro:Product Name:ecallantide
CAS:460738-38-9
Purity:99.9% Package:25kgs/Drum;200kgs/Drum Remarks:FDA GMP CEP Approved Manufacturer - CB Index:58
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- Company Name:Wuxi Helen Biotechnology Co., Ltd.,
- Tel:0510-85629785 18013409632
- Products Intro:Product Name:ecallantide
CAS:460738-38-9
Purity:95%+ Package:根据客户需求包装 - CB Index:58
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