443104-02-7

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CDDO Imidozolide (CDDO-Im) is a synthetic triterpenoid CDDO-Im inhibits fatty acid synthase expression and has antiproliferative and proapoptotic effects in human liposarcoma cells. Studies show that CDDO-Im is highly active in suppressing cellular proliferation of human leukemia and breast cancer cell lines as well as being an effective therapeutic agent in the treatment of other types of cancers .

CDDO-Im is a bifunctional CDDO analog th at enhances NRF2-mediated antioxidant and anti-inflammatory activity by forming not only KEAP1 covalent adducts (Michael adducts via cysteinesacyl adducts via lysines and tyrosines) in the same manner as CDDO and CDDO-Mebut also by covalently transacylating arginine and serine residues in GSTP and cross-linking them to adjacent cysteine residues. CDDO-Im is typically used in the range of 1-40 nM in cultures2-5.5 mg/kg via i.p. and 2.5 mg/kg via i.v. in vivo (mice and rats).

PPARα: 232 nM (Ki); PPARγ: 344 nM (Ki); Nrf2

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