ChemicalBook CAS DataBase List 4330-99-8

4330-99-8

Name	Trimeprazine tartrate
CAS	4330-99-8
EINECS(EC#)	224-368-9
Molecular Formula	C40H50N4O6S2
MDL Number	MFCD00242594
Molecular Weight	746.98
MOL File	4330-99-8.mol

Synonyms

alimemazine tartrate n,n,2-trimethyl-3-phenothiazin-10-yl-propan-1-amine tartrate TRIMEPRAZINE HEMI-(+)-TARTRATE SALT TRIMEPRAZINE TARTRATE TRIMEPRAZINE TARTRATE(R)(2:1) 10-(3-(dimethylamino)-2-methylpropyl)phenothiazinetartrate 10-(3-(dimethylamino)-2-methylpropyl)-phenothiazintartrate(2:1) panectyl repeltin temaril theralene vallergan vanectyl trimeprazine hemi-(+)tartrate HydroxystilbamidineIsothionate 10H-Phenothiazine-10-propanamine, N,N,β-trimethyl-, (2R,3R)-2,3-dihydroxybutanedioate (2:1) 10H-Phenothiazine-10-propanamine, N,N,β-trimethyl-, [R-(R*,R*)]-2,3-dihydroxybutanedioate (2:1) NSC 17475 Phenothiazine, 10-[3-(dimethylamino)-2-methylpropyl]-, tartrate (2:1) (8CI) Temaril 16

Chemical Properties

Melting point	153-155°C
storage temp.	Inert atmosphere,Room Temperature
solubility	DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: 5 mg/ml; PBS (pH 7.2): insol
form	neat
color	White to Almost white
Merck	14,9704
Major Application	pharmaceutical (small molecule)
InChIKey	ZEEPCWVFSHMOPI-MVELKYERNA-N
SMILES	C(N1C2=CC=CC=C2SC2C=CC=CC1=2)C(C)CN(C)C.[C@H](O)(C(=O)O)[C@@H](O)C(=O)O \|&1:21,26,r\|
CAS DataBase Reference	4330-99-8(CAS DataBase Reference)

Safety Data

Symbol(GHS)	GHS06
Signal word	Danger
Hazard statements	H301
Precautionary statements	P301+P330+P331+P310
Hazard Codes	Xn
Risk Statements	R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . less more
Safety Statements	S36:Wear suitable protective clothing . less more
RIDADR	3249
WGK Germany	3
RTECS	SO6475000
HazardClass	6.1(b)
PackingGroup	III
HS Code	2934302700
Storage Class	6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects
Hazard Classifications	Acute Tox. 3 Oral

Hazard Information

Chemical Properties

White to Off-White Solid

Uses

Antipruritic. Antibacterial, antimicrobial agent

Brand name

Temaril (Allergan).

General Description

Trimeprazine tartrate, (±)10-[3-(dimethylamino)-2-methylpropyl] phenothiazine tartrate(Temaril), occurs as a white to off-white crystalline powderthat is freely soluble in water and soluble in alcohol. Its antihistaminicaction is reported to be from 1.5 to 5 times thatof promethazine. Clinical studies have shown it has a pronouncedantipruritic action that may be unrelated to itshistamine-antagonizing properties.

in vivo

Alimemazine hemitartrate (10 mg/kg, intraperitoneal injection, once a day for 3 weeks) promotes mouse β-cell growth^[2].
Alimemazine hemitartrate (10 mg/kg, intraperitoneal injection, once a day for 22 days) synergistically reduces the progression of diabetes in NOD mice^[2].
Alimemazine hemitartrate (10 mg/kg, intraperitoneal injection, once a day for 7 days) promotes the proliferation and survival of β-cells in normal mice, but has little effect on β-cell defects caused by IRS2 deficiency^[2].
Alimemazine hemitartrate (10 mg/kg, oral gavage, two doses) does not reduce mouse lung virus titers^[3].

Animal Model:	Pdx1^+/– mice^[2]
Dosage:	10 mg/kg, once a day for 3 weeks
Administration:	Intraperitoneal injection (i.p.)
Result:	Increased HOMA 2%B and normalized glucose tolerance in mice.

Animal Model:	Irs2^-/–mice^[2]
Dosage:	10 mg/kg, once a day for seven days
Administration:	Intraperitoneal injection (i.p.)
Result:	Did not restore the function of β cells, but promoted β cell growth and increased the area of β cells in normal mice. Increased the concentration of IRS2 protein, had no effect on glucose tolerance in mice, and did not change the insulin sensitivity of mice.

Animal Model:	SARS-CoV-2 multiplication in mice^[3]
Dosage:	10mg/kg, at 1 h prior to and 24 h after virus inoculation
Administration:	i.g.
Result:	Did not reduce lung virus titers.

IC 50

GPCR

Spectrum Detail

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