425613-09-8

2-(4-Ethylphenoxy)-N-(4-fluoro-3-nitrophenyl)acetamide is a canonical bone morphogenetic proteins (BMP) signaling pathway activator.

SJ000291942 is an activator of Bone Morphogenetic Protein (BMP) signaling with an EC50 value < 1 μM. Bone Morphogenetic Proteins (BMPs) are a group of growth factors and cytokines were originally discovered by their ability to induce the formation of bone and cartilagebut are now considered to constitute a group of pivotal morphogenetic signalsorchestrating tissue architecture throughout the body. SJ000291942 was shown to ventralize zebrafish embryosactivate SMAD1/5/8 phosphorylationand induce the differentiation of C2C12 myoblasts to osteoblasts in manner consistent with BMP4 activation.