Description
Isazofos is a yellow liquid. Solubility in water is 168 mg/L (20 ?C). It is
miscible with common organic solvents. Log Kow = 2.99.
It is hydrolyzed in aqueous media: DT50 values (20 ?C) at
pH 5, 7, and 9 are 85, 48, and 19 d, respectively.
Uses
Isazofos is used as a nematicide and soil insecticide in bananas,
citrus, cotton, beet, maize, rice, vegetables, sugar cane and turf.
Uses
Nematocide; turf insecticide.
Definition
ChEBI: Isazofos is an organic thiophosphate.
Metabolic pathway
Isazofos is metabolised in soil to its hydrolysis product 5-chloro-1-
isopropyl-3-triazolol. The oxon metabolite has apparently not been
identified.
Metabolism
In mammals, administered isazofos is
rapidly metabolized and excreted, primarily in the urine,
without accumulation in the body. The degradation route
of isazofos in soil is primarily the hydrolysis mediated
by microorganisms to give 5-chloro-1-isopropyl-3-triazole.
The half-life in soils is about 10 d.
Degradation
Isazofos is hydrolysed more rapidly in alkaline rather than acid solution.
The DT50 values at pH 5, 7 and 9 were 85, 48 and 19 days, respectively
(PM).
Toxicity evaluation
Acute oral LD50 for rats is
40–60 mg/kg. Inhalation LC50 (4 h) for rats is about
0.24 mg/L air. NOEL (90 d) for rats is 2 mg/kg diet
(0.1 mg/kg/d).
